Calcitriol induces cell senescence of kidney cancer through JMJD3 mediated histone demethylation.

ABSTRACT: Calcitriol, also known as 1,25-dihydroxyvitamin D3 (1,25(OH)₂VD₃), is a biologically active form of vitamin D and has a wide range of anticancer activity against various cancer cell lines. However, the mechanism of calcitriol remains to be further studied. In this study, the biological effect and epigenetic regulation of calcitriol on kidney cancer cells were investigated. Calcitriol can significantly inhibit cell proliferation of kidney cancer cell lines 786-O (P<0.05). Calcitriol also induced cell apoptosis and senescence of 786-O and ACHN (P<0.05). Calcitriol can increase the expression of histone demethylase JMJD3 and cell senescence marker p16INK4A (P<0.05). Knockdown of JMJD3 decreased p16INK4A upregulation after calcitriol treatment (P</

SUBMITTER: Shen Y 

PROVIDER: S-EPMC5725012 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature