Kruppel-like factor 2 suppresses human gastric tumorigenesis through inhibiting PTEN/AKT signaling.

ABSTRACT: Krüppel-like factors (KLFs) are a large family of DNA-binding transcriptional regulators that affect basic cellular processes such as growth, survival, migration and differentiation and serve a complicated function in cancers. KLF2, one member of the KLF family, is dysregulated in many tumors. However, the specific role of KLF2 in human gastric tumorigenesis is unknown. Here we show that the expression of KLF2 protein was lower in gastric tumors when compared with adjacent normal tissue. Moreover, downregulated KLF2 expression in primary gastric tumor was closely correlated with patients' survival. Various cell experiments showed that ectopic KLF2 expression suppressed the proliferation, migration and invasion of gastric cancer cells. Moreover, KLF2 overexpression remarkably enhanced cell

SUBMITTER: Wang C 

PROVIDER: S-EPMC5725026 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature