Clinicopathological and prognostic significance of HMGA2 overexpression in gastric cancer: a meta-analysis.

ABSTRACT:

Background

High mobility group protein A2 (HMGA2) overexpression has been reported to be closely related to tumor progression [1-4] and indicate significantly worse overall survival in gastric cancer [5-8]. However, a final consensus regarding this issue has not yet been reached. Thus, we conducted a meta-analysis to evaluate the association between HMGA2 expression and prognosis of gastric cancer patients.

Methods

The Cochrane Library, Embase, PubMed, Web of Science and China Biology Medicine databases were searched to identify eligible literature published prior to September 2016. In the included studies, the level of HMGA2 amplification was evaluated by immunohistochemistry. We performed a meta-analysis, and pooled relative risk (RRs), hazard ratio (HRs), and 95% confiden

SUBMITTER: Zhu J 

PROVIDER: S-EPMC5725036 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature