Effects of levosimendan on mortality in patients with septic shock: systematic review with meta-analysis and trial sequential analysis.

ABSTRACT:

Object

Several studies have investigated a survival benefit for levosimendan treatment in patients with septic shock. However, data are conflicting. We conducted a meta-analysis to evaluate the effect of levosimendan treatment on mortality in patients with septic shock.

Materials and methods

We searched PubMed, EMBASE and Cochrane Library Databases up to March 27, 2017, without language restrictions. We searched for terms related to septic shock, levosimendan, randomized clinical trial. Randomized controlled trials reported the effect of levosimendan on mortality were included. Moreover, we constructed the trial sequential analysis (TSA) to determine the reliability of the outcomes. Furthermore, secondary outcomes were cardiac index(CI), mean arterial pressure (MAP), blood l

SUBMITTER: Wang B 

PROVIDER: S-EPMC5725040 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature