Evaluation of the NMP22 BladderChek test for detecting bladder cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

We examined the usefulness of the nuclear matrix protein 22 (NMP22) BladderChek test for detecting bladder cancer.

Materials and methods

A literature search was performed using PubMed, Embase, the Cochrane Library, and Web of Science. The diagnostic accuracy of the NMP22 BladderChek test was evaluated via pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under curve (AUC). Inter-study heterogeneity was explored using meta-regression and subgroup analyses.

Results

We included 23 studies in the systematic review and 19 in the quantitative meta-analysis. Overall sensitivity and specificity were 56% (52-59%) and 88% (87-89%), respectively; pooled PLR and NLR were 4.36 (3.02-6

SUBMITTER: Wang Z 

PROVIDER: S-EPMC5725051 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature