Aflatoxin B₁ affects apoptosis and expression of death receptor and endoplasmic reticulum molecules in chicken spleen.

ABSTRACT: Aflatoxin B₁ (AFB₁) is a natural product of the Aspergillus genus of molds, which grow on several foodstuffs stored in hot moist conditions, and is among the most potent hepatocarcinogens and immunosuppression presently known. The latter was related to the up-regulated apoptosis of immune organs. However, the effect of expression of death receptor and endoplasmic reticulum molecules in AFB₁-induced apoptosis of chicken splenocytes was largely unknown. The objective of this study was to investigate this unknown field. One hundred and forty four one-day-old chickens were randomly divided into control group (0 mg/kg AFB₁) and AFB₁ group (0.6 mg/kg AFB₁), respectively and fed with AFB₁ for 21 days. Histological observ

SUBMITTER: Zhu P 

PROVIDER: S-EPMC5725112 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature