Extracellular vesicles from KSHV-infected endothelial cells activate the complement system.

ABSTRACT: Extracellular vesicles (EVs), released by cells, are associated with cell-to-cell communication and regulate various cellular processes. EVs draw parallels with viruses for their similar structures and functions. Increasing evidences from recent studies indicate that cells infected with viruses release a variety of EVs. Delineating the functions and mechanisms of EVs released during virus infection is essential for understanding the molecular basis of viral infection and replication as well as associated pathogenesis. The most challenging obstacle for these studies is the separation of EVs from viruses. In this study, we successfully isolated the EVs from de novo Kaposi's sarcoma-associated herpesvirus (KSHV) infected-human endothelial cells during the period between virus entry and

SUBMITTER: Jeon H 

PROVIDER: S-EPMC5725135 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature