Ontology highlight
ABSTRACT:
SUBMITTER: Edupuganti RR
PROVIDER: S-EPMC5725193 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Edupuganti Raghu R RR Geiger Simon S Lindeboom Rik G H RGH Shi Hailing H Hsu Phillip J PJ Lu Zhike Z Wang Shuang-Yin SY Baltissen Marijke P A MPA Jansen Pascal W T C PWTC Rossa Martin M Müller Markus M Stunnenberg Hendrik G HG He Chuan C Carell Thomas T Vermeulen Michiel M
Nature structural & molecular biology 20170904 10
RNA modifications are integral to the regulation of RNA metabolism. One abundant mRNA modification is N<sup>6</sup>-methyladenosine (m<sup>6</sup>A), which affects various aspects of RNA metabolism, including splicing, translation and degradation. Current knowledge about the proteins recruited to m<sup>6</sup>A to carry out these molecular processes is still limited. Here we describe comprehensive and systematic mass-spectrometry-based screening of m<sup>6</sup>A interactors in various cell type ...[more]