Genome-scale model guided design of Propionibacterium for enhanced propionic acid production.

ABSTRACT: Production of propionic acid by fermentation of propionibacteria has gained increasing attention in the past few years. However, biomanufacturing of propionic acid cannot compete with the current oxo-petrochemical synthesis process due to its well-established infrastructure, low oil prices and the high downstream purification costs of microbial production. Strain improvement to increase propionic acid yield is the best alternative to reduce downstream purification costs. The recent generation of genome-scale models for a number of Propionibacterium species facilitates the rational design of metabolic engineering strategies and provides a new opportunity to explore the metabolic potential of the Wood-Werkman cycle. Previous strategies for strain improvement have individually targeted

SUBMITTER: Navone L 

PROVIDER: S-EPMC5725212 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature