Metabolism of hydrogen sulfide (H₂S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase.

ABSTRACT: Reactive sulfur species (RSS) such as H₂S, HS^•, H₂S_n, (n = 2-7) and HS₂^•- are chemically similar to H₂O and the reactive oxygen species (ROS) HO^•, H₂O₂, O₂^•- and act on common biological effectors. RSS were present in evolution long before ROS, and because both are metabolized by catalase it has been suggested that "antioxidant" enzymes originally evolved to regulate RSS and may continue to do so today. Here we examined RSS metabolism by Cu/Zn superoxide dismutase (SOD) using amperometric electrodes for dissolved H₂S, a polysulfide-specific fluorescent probe (SSP4), and mass spectrometry to identify specific polysulfides (H₂S₂-

SUBMITTER: Olson KR 

PROVIDER: S-EPMC5725220 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature