Cell protrusion and retraction driven by fluctuations in actin polymerization: A two-dimensional model.

ABSTRACT: Animal cells that spread onto a surface often rely on actin-rich lamellipodial extensions to execute protrusion. Many cell types recently adhered on a two-dimensional substrate exhibit protrusion and retraction of their lamellipodia, even though the cell is not translating. Travelling waves of protrusion have also been observed, similar to those observed in crawling cells. These regular patterns of protrusion and retraction allow quantitative analysis for comparison to mathematical models. The periodic fluctuations in leading edge position of XTC cells have been linked to excitable actin dynamics using a one-dimensional model of actin dynamics, as a function of arc-length along the cell. In this work we extend this earlier model of actin dynamics into two dimensions (along the arc-length a

SUBMITTER: Ryan GL 

PROVIDER: S-EPMC5725282 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature