Volumetric grey matter alterations in adolescents and adults born very preterm suggest accelerated brain maturation.

ABSTRACT: Previous research investigating structural neurodevelopmental alterations in individuals who were born very preterm demonstrated a complex pattern of grey matter changes that defy straightforward summary. Here we addressed this problem by characterising volumetric brain alterations in individuals who were born very preterm from adolescence to adulthood at three hierarchically related levels - global, modular and regional. We demarcated structural components that were either particularly resilient or vulnerable to the impact of very preterm birth. We showed that individuals who were born very preterm had smaller global grey matter volume compared to controls, with subcortical and medial temporal regions being particularly affected. Conversely, frontal and lateral parieto-temporal cortices w

SUBMITTER: Karolis VR 

PROVIDER: S-EPMC5725310 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature