Transcriptome Sequencing Reveals Astrocytes as a Therapeutic Target in Heat-Stroke.

ABSTRACT: Heat-stroke is a serious form of hyperthermia with high mortality, and can induce severe central nervous system disorders. The neurovascular unit (NVU), which consists of vascular cells, glial cells, and neurons, controls blood-brain barrier (BBB) permeability and cerebral blood flow, and maintains the proper functioning of neuronal circuits. However, the detailed function of each BBB component in heat-stroke remains unknown. In order to interpret alterations caused by heat stress, we performed transcriptome comparison of neuron and astrocyte primary cultures after heat treatment. Differentially-expressed genes were then selected and underwent Gene Ontology annotation and Kyoto Encyclopedia of Genes and Genomes pathway analysis. Gene-act networks were also constructed, and the expression o

SUBMITTER: Niu B 

PROVIDER: S-EPMC5725376 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature