A novel Tn1696-like composite transposon (Tn6404) harboring bla _IMP-4 in a Klebsiella pneumoniae isolate carrying a rare ESBL gene bla _SFO-1.

ABSTRACT: Genetic determinants of a clinical Klebsiella pneumoniae isolate (KP1814) coproducing IMP-4 and a rare ESBL gene SFO-1 was investigated. KP1814 belongs to a novel sequence type (ST) assigned to ST2270. WGS identified four circular DNA sequences in KP1814, including two multidrug-resistance (MDR) plasmids, one virulence plasmid, and one circular form. The MDR plasmid pKP1814-1 (299.9 Kb) is untypeable, and carries two large mosaic multiresistance regions (MRRs). bla _SFO-1 and bla _IMP-4 co-exists on MRR1, and bla _SFO-1 is associated with an IS/Tn-independent genetic context. bla _IMP-4 is carried by a novel In804-like integron (intlI-bla _IMP-4-Kl.pn.I3-qacG2-aacA4-catB3∆) associated with a novel Tn1696-like transposon (designed Tn6404) fl

SUBMITTER: Zhou K 

PROVIDER: S-EPMC5725488 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature