Exploring the relationship between polio type 2 serum neutralizing antibodies and intestinal immunity using data from two randomized controlled trials of new bOPV-IPV immunization schedules.

ABSTRACT:

Background

Inactivated polio vaccine (IPV) is now the only source of routine type 2 protection. The relationship, if any, between vaccine-induced type 2 humoral and intestinal immunity is poorly understood.

Methods

Two clinical trials in five Latin American countries of mixed or sequential bOPV-IPV schedules in 1640 infants provided data on serum neutralizing antibodies (NAb) and intestinal immunity, assessed as viral shedding following oral mOPV2 challenge. Analyses with generalized additive and quantile regression models examined the relationships between prechallenge NAb titers and proportion, duration and titers (magnitude) of viral shedding.

Results

We found a statistically significant (p < .0001) but weak relationship between NAb titer at the time of mOPV2 chall

SUBMITTER: Bandyopadhyay AS 

PROVIDER: S-EPMC5725506 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature