Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer.

ABSTRACT: Oestrogen controls Foxp3 expression in regulatory T cells (T_reg cells) via a mechanism thought to involve oestrogen receptor alpha (ERα), but the molecular basis and functional impact of ERα signalling in T_reg cells remain unclear. We report that ERα ligand oestradiol (E2) is significantly increased in human cervical cancer (CxCa) tissues and tumour-infiltrating T_reg cells (CD4⁺CD25^hiCD127^low), whereas blocking ERα with the antagonist ICI 182,780 abolishes FOXP3 expression and impairs the function of CxCa infiltrating T_reg cells. Using a novel approach of co-immunoprecipitation with antibodies to E2 for capture, we identified binding of E2:ERα complexes to FOXP3 protein in CxCa-derived T_reg cells. Chrom

SUBMITTER: Adurthi S 

PROVIDER: S-EPMC5725534 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature