In Silico Studies Revealed Multiple Neurological Targets for the Antidepressant Molecule Ursolic Acid.

ABSTRACT:

Background

Ursolic acid, a bioactive pentacyclic triterpenoid had been evaluated for its interaction with the neurological targets associated with antidepressant drugs. Current study was to mechanistically analyze the probable site of action for ursolic acid on the target proteins.

Methods

Ursolic acid has been docked with monoamine oxidase isoforms: MAO-A and MAO-B, LeuT (homologue of SERT, NET, DAT) and Human C-terminal CAP1 using GRIP docking methodology.

Results

Results revealed its non-selective antidepressant action with strong binding affinity towards LeuT and MAO-A proteins, which was found to be comparable with the reference ligands like chlorgyline, clomipramine, sertraline and deprenyl/selegiline.

Conclusion

Significant binding affinity of ursolic ac

SUBMITTER: Singla RK 

PROVIDER: S-EPMC5725542 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature