CHRNA7 Deletions are Enriched in Risperidone-Treated Children and Adolescents.

ABSTRACT:

Objective

Aggression is among the most common indications for referral to child and adolescent mental health services and is often challenging to treat. Understanding the biological underpinnings of aggression could help optimize treatment efficacy. Neuronal nicotinic acetylcholine receptors (nAChRs), specifically the α7 nAChR, encoded by the gene CHRNA7, have been implicated in aggressive behaviors in animal models as well as humans. Copy number variants (CNVs) of CHRNA7 are found in individuals with neuropsychiatric disorders, often with comorbid aggression. In this study, we aimed to determine the prevalence of CHRNA7 CNVs among individuals treated with risperidone, predominantly for irritability and aggression.

Methods

Risperidone-treated children and adolescents were as

SUBMITTER: Gillentine MA 

PROVIDER: S-EPMC5725633 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature