Possible positive effect of the APOE ε2 allele on cognition in early to mid-adult life.

ABSTRACT:

Background

ε4 allele possession is associated with an increased risk of Alzheimer's disease. Its effects earlier in life are less well understood. Previous studies have reported both detrimental effects and a lack of effect on cognition outside dementia. We used genotype based recall from the ALSPAC study to investigate whether APOE genotype influences cognition in earlier adult life.

Methods

We invited all individuals with the rarer ε22 or ε44 genotypes and equal numbers of those with ε32, ε33 or ε34 APOE genotypes (total n invited = 1936, ages 23-67). Participants were screened for dementia using the Addenbrooke's Cognitive Examination Revised (ACE-R). Participants were asked to complete a 3 h battery of neuropsychological tests covering a range of cognitive domains. The p

SUBMITTER: Sinclair LI 

PROVIDER: S-EPMC5725639 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature