Adenocarcinoma risk in gastric atrophy and intestinal metaplasia: a systematic review.

ABSTRACT:

Background

Gastric cancer (GC) has a poor prognosis with wide variation in survival rates across the world. Several studies have shown premalignant lesions gastric atrophy (GA) and intestinal metaplasia (IM) influence gastric cancer risk. This systematic review examines all available evidence of the risk of GC in patients with GA or IM and explores the geographical variation between countries.

Methods

EMBASE, MEDLINE, Web of Science and the Cochrane Library were searched for relevant articles published to June 2016 investigating the risk of GC in individuals with GA or IM. Analysis was performed to determine variation based on geographical location. Study quality was assessed using the Newcastle-Ottawa Scale and heterogeneity between studies was also evaluated.

Results

SUBMITTER: Spence AD 

PROVIDER: S-EPMC5725642 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature