Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth.

ABSTRACT:

Background

Identification of factors that influence the neonatal gut microbiome is urgently needed to guide clinical practices that support growth of healthy preterm infants. Here, we examined the influence of nutrition and common practices on the gut microbiota and growth in a cohort of preterm infants.

Results

With weekly gut microbiota samples spanning postmenstrual age (PMA) 24 to 46 weeks, we developed two models to test associations between the microbiota, nutrition and growth: a categorical model with three successive microbiota phases (P1, P2, and P3) and a model with two periods (early and late PMA) defined by microbiota composition and PMA, respectively. The more significant associations with phase led us to use a phase-based framework for the majority of our analy

SUBMITTER: Grier A 

PROVIDER: S-EPMC5725645 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature