The anterior insula bidirectionally modulates cost-benefit decision-making on a rodent gambling task.

ABSTRACT: Deficits in cost-benefit decision-making, as assessed in the Iowa Gambling Task (IGT), are commonly observed in neuropsychiatric disorders such as addiction. There is considerable variation in the maximization of rewards on such tasks, both in the general population and in rodent models, suggesting individual differences in decision-making may represent a key endophenotype for vulnerability to neuropsychiatric disorders. Increasing evidence suggests that the insular cortex, which is involved in interoception and emotional processes in humans, may be a key neural locus in the control of decision-making processes. However, the extent to which the insula contributes to individual differences in cost-benefit decision-making remains unknown. Using male Sprague Dawley rats, we first assessed ind

SUBMITTER: Daniel ML 

PROVIDER: S-EPMC5725664 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature