Chemical warfare agent simulants for human volunteer trials of emergency decontamination: A systematic review.

ABSTRACT: Incidents involving the release of chemical agents can pose significant risks to public health. In such an event, emergency decontamination of affected casualties may need to be undertaken to reduce injury and possible loss of life. To ensure these methods are effective, human volunteer trials (HVTs) of decontamination protocols, using simulant contaminants, have been conducted. Simulants must be used to mimic the physicochemical properties of more harmful chemicals, while remaining non-toxic at the dose applied. This review focuses on studies that employed chemical warfare agent simulants in decontamination contexts, to identify those simulants most suitable for use in HVTs of emergency decontamination. Twenty-two simulants were identified, of which 17 were determined unsuitable for use i

SUBMITTER: James T 

PROVIDER: S-EPMC5725685 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature