Alcohol and Stress Activation of Microglia and Neurons: Brain Regional Effects.

ABSTRACT:

Background

Cycles of alcohol and stress are hypothesized to contribute to alcohol use disorders. How this occurs is poorly understood, although both alcohol and stress activate the neuroimmune system-the immune molecules and cells that interact with the nervous system. The effects of alcohol and stress on the neuroimmune system are mediated in part by peripheral signaling molecules. Alcohol and stress both enhance immunomodulatory molecules such as corticosterone and endotoxin to impact neuroimmune cells, such as microglia, and may subsequently impact neurons. In this study, we therefore examined the effects of acute and chronic ethanol (EtOH) on the corticosterone, endotoxin, and microglial and neuronal response to acute stress.

Methods

Male Wistar rats were treated intraga

SUBMITTER: Walter TJ 

PROVIDER: S-EPMC5725687 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature