Revisiting Hansen Solubility Parameters by Including Thermodynamics.

ABSTRACT: The Hansen solubility parameter approach is revisited by implementing the thermodynamics of dissolution and mixing. Hansen's pragmatic approach has earned its spurs in predicting solvents for polymer solutions, but for molecular solutes improvements are needed. By going into the details of entropy and enthalpy, several corrections are suggested that make the methodology thermodynamically sound without losing its ease of use. The most important corrections include accounting for the solvent molecules' size, the destruction of the solid's crystal structure, and the specificity of hydrogen-bonding interactions, as well as opportunities to predict the solubility at extrapolated temperatures. Testing the original and the improved methods on a large industrial dataset including solvent blends, f

SUBMITTER: Louwerse MJ 

PROVIDER: S-EPMC5725732 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature