Serum tau and neurological outcome in cardiac arrest.

ABSTRACT:

Objective

To test serum tau as a predictor of neurological outcome after cardiac arrest.

Methods

We measured the neuronal protein tau in serum at 24, 48, and 72 hours after cardiac arrest in 689 patients in the prospective international Target Temperature Management trial. The main outcome was poor neurological outcome, defined as Cerebral Performance Categories 3-5 at 6 months.

Results

Increased tau was associated with poor outcome at 6 months after cardiac arrest (median = 38.5, interquartile range [IQR] = 5.7-245ng/l in poor vs median = 1.5, IQR = 0.7-2.4ng/l in good outcome, for tau at 72 hours, p < 0.0001). Tau improved prediction of poor outcome compared to using clinical information (p < 0.0001). Tau cutoffs had low false-positive rates (FPRs) for good outcome

SUBMITTER: Mattsson N 

PROVIDER: S-EPMC5725735 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature