Dataset Information
Serum tau and neurological outcome in cardiac arrest.
Ontology highlight
ABSTRACT: Objective
To test serum tau as a predictor of neurological outcome after cardiac arrest.Methods
We measured the neuronal protein tau in serum at 24, 48, and 72 hours after cardiac arrest in 689 patients in the prospective international Target Temperature Management trial. The main outcome was poor neurological outcome, defined as Cerebral Performance Categories 3-5 at 6 months.Results
Increased tau was associated with poor outcome at 6 months after cardiac arrest (median?=?38.5, interquartile range [IQR]?=?5.7-245ng/l in poor vs median?=?1.5, IQR?=?0.7-2.4ng/l in good outcome, for tau at 72 hours, p?InterpretationSerum tau is a promising novel biomarker for prediction of neurological outcome in patients with cardiac arrest. It may be significantly better than serum NSE, which is recommended in guidelines and currently used in clinical practice in several countries to predict outcome after cardiac arrest. Ann Neurol 2017;82:665-675.
SUBMITTER: Mattsson N
PROVIDER: S-EPMC5725735 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Serum tau and neurological outcome in cardiac arrest.
Annals of neurology 20171102 5
<h4>Objective</h4>To test serum tau as a predictor of neurological outcome after cardiac arrest.<h4>Methods</h4>We measured the neuronal protein tau in serum at 24, 48, and 72 hours after cardiac arrest in 689 patients in the prospective international Target Temperature Management trial. The main outcome was poor neurological outcome, defined as Cerebral Performance Categories 3-5 at 6 months.<h4>Results</h4>Increased tau was associated with poor outcome at 6 months after cardiac arrest (median ...[more]
