Multiple breath washout testing in adults with pulmonary disease and healthy controls - can fewer measurements eventually be more?

ABSTRACT:

Background

Multiple breath washout (MBW) became a valuable research tool assessing ventilation heterogeneity. However, routine clinical application still faces several challenges. Deriving MBW parameters from three technically acceptable measurements according to current recommendations prolongs test times. We therefore aimed to evaluate reporting only duplicate measurements in healthy adults and pulmonary disease.

Methods

One hundred and fifty-three subjects prospectively underwent conventional lung function testing and closed-circuit SF₆-MBW. Three technically acceptable MBW-measurements were obtained in 103 subjects.

Results

Lung clearance index (LCI) differed significantly among 19 controls (7.4 ± 0.8), 19 patients with sarcoidosis (8.1 ± 1.2), 32 with

SUBMITTER: Trinkmann F 

PROVIDER: S-EPMC5725793 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature