Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease.

ABSTRACT:

Background

The role of single nucleotide polymorphisms (SNPs) associated with inflammatory bowel disease (IBD) is gaining interest. With the advent of novel therapies, personalized treatment in IBD is a future goal. We wondered whether IBD-associated SNPs are able to predict response to anti-TNFα treatment.

Methods

Data on treatment use and primary response, loss of response and side effects to anti-TNFα treatments were retrieved for 570 IBD patients. rs13361189 (IRGM), rs10210302 (ATG16L1), rs2066844, rs2066845, rs2066847 (NOD2), rs35873774 (XBP1), rs11175593 (LRRK2), rs11465804 (IL23R), rs2301436 (CCR6), rs744166 (STAT3) and rs4821544 (NCF4) SNP status were determined.

Results

No associations were found between genetic variants of the LRRK2, CCR6, IL23R and NCF4 gen

SUBMITTER: Nuij VJAA 

PROVIDER: S-EPMC5725822 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature