Association between risk of asthma and gene polymorphisms in CHI3L1 and CHIA: a systematic meta-analysis.

ABSTRACT:

Background

Previous studies have indicated that chitinase 3-like 1 (CHI3L1) gene rs4950928 polymorphism and acidic mammalian chitinase (AMCase or CHIA) gene rs10494132 polymorphism are associated with the risk of asthma. However, the results are inconsistent because of small sample size and varied ethnicity and age in studies. Therefore, a systematic meta-analysis was important to clarify the effect of CHI3L1 rs4950928 polymorphism and CHIA rs10494132 variant on asthma risk.

Methods

An electronic literature search was conducted to identify all the eligible studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated and sensitivity analysis as well as publication bias were assessed to investigate the associations. All statistical analyses were performed usi

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC5726029 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature