Association between human herpesvirus infections and dementia or mild cognitive impairment: a systematic review protocol.

ABSTRACT:

Introduction

Persisting neurotropic viruses are proposed to increase the risk of dementia, but evidence of association from robust, adequately powered population studies is lacking. This is essential to inform clinical trials of targeted preventive interventions.

Methods and analysis

We will carry out a comprehensive systematic review of published and grey literature of the association between infection with, reactivation of, vaccination against or treatment of any of the eight human herpesviruses and dementia or mild cognitive impairment. We will search the Cochrane Library, Embase, Global Health, Medline, PsycINFO, Scopus, Web of Science, clinical trials registers, the New York Academy of Medicine Grey Literature Report, Electronic Theses Online Service through the British

SUBMITTER: Warren-Gash C 

PROVIDER: S-EPMC5726086 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature