Model-based methods for case definitions from administrative health data: application to rheumatoid arthritis.

ABSTRACT:

Objective

This research proposes a model-based method to facilitate the selection of disease case definitions from validation studies for administrative health data. The method is demonstrated for a rheumatoid arthritis (RA) validation study.

Study design and setting

Data were from 148 definitions to ascertain cases of RA in hospital, physician and prescription medication administrative data. We considered: (A) separate univariate models for sensitivity and specificity, (B) univariate model for Youden's summary index and (C) bivariate (ie, joint) mixed-effects model for sensitivity and specificity. Model covariates included the number of diagnoses in physician, hospital and emergency department records, physician diagnosis observation time, duration of time between physician

SUBMITTER: Kroeker K 

PROVIDER: S-EPMC5726099 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature