Eugenol Induces Phenotypic Alterations and Increases the Oxidative Burst in Cryptococcus.

ABSTRACT: Eugenol is a phenolic compound and the main constituent of the essential oil of clove India. Although there are reports of some pharmacological effects of eugenol, this study is the first that proposes to evaluate the antifungal effects of this phenol against both Cryptococcus gattii and C. neoformans cells. The effect of eugenol against yeast cells was analyzed for drug susceptibility, alterations in cell diameter, capsule properties, amounts of ergosterol, oxidative burst, and thermodynamics data. Data demonstrated that there is no interaction between eugenol and fluconazole and amphotericin B. Eugenol reduced the cell diameter and the capsule size, increased cell surface/volume, changed positively the cell surface charge of cryptococcal cells. We also verified increased levels of reacti

SUBMITTER: Alves JCO 

PROVIDER: S-EPMC5726113 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature