Corticosteroids in sepsis: an updated systematic review and meta-analysis (protocol).

ABSTRACT:

Introduction

Sepsis is associated with a dysregulated host response to infection and impaired endogenous corticosteroid metabolism. As such, therapeutic use of exogenous corticosteroids is a promising adjunctive intervention. Despite a large number of trials examining this research question, uncertainty persists regarding the effect of corticosteroids on survival in sepsis. Several large randomised controlled trials have been published recently prompting a re-evaluation of the available literature.

Methods and analysis

A rigorous and reproducible search and screening process from a Cochrane review on the same topic was comprehensive to October 2014. We will search MEDLINE, EMBASE, LILACS, the Cochrane trial registry and clinicaltrials.gov for eligible randomised controlled t

SUBMITTER: Rochwerg B 

PROVIDER: S-EPMC5726130 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature