Robust Estimation of Electron Density From Anatomic Magnetic Resonance Imaging of the Brain Using a Unifying Multi-Atlas Approach.

ABSTRACT:

Purpose

To develop a reliable method to estimate electron density based on anatomic magnetic resonance imaging (MRI) of the brain.

Methods and materials

We proposed a unifying multi-atlas approach for electron density estimation based on standard T1- and T2-weighted MRI. First, a composite atlas was constructed through a voxelwise matching process using multiple atlases, with the goal of mitigating effects of inherent anatomic variations between patients. Next we computed for each voxel 2 kinds of conditional probabilities: (1) electron density given its image intensity on T1- and T2-weighted MR images; and (2) electron density given its spatial location in a reference anatomy, obtained by deformable image registration. These were combined into a unifying posterior probabili

SUBMITTER: Ren S 

PROVIDER: S-EPMC5726227 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature