Gene expression profiling in the intestinal mucosa of obese rats administered probiotic bacteria.

ABSTRACT: We investigated whether the administration of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 modulate the expression of genes in the intestinal mucosa of obese Zucker rats. Forty-eight Zucker-Lepr^fa/fa and 16 Zucker lean Lepr^+/fa rats were used. Eight Zucker lean Lepr^+/fa and 8 Zucker-Lepr^fa/fa rats were euthanized as a reference. The remaining 40 Zucker-Lepr^fa/fa rats were then assigned to receive 10¹⁰ colony forming units (CFU) of one of the three probiotic strains, a mixture of L. paracasei CNCM I-4034 and B. breve CNCM I-4035, or a placebo by oral administration for 30 days. An additional group of 8 Zucker lean Lepr^+/fa rats received the placebo f

SUBMITTER: Plaza-Diaz J 

PROVIDER: S-EPMC5726311 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature