An RNA-Seq atlas of gene expression in mouse and rat normal tissues.

ABSTRACT: Gene functionality is closely connected to its expression specificity across tissues and cell types. RNA-Seq is a powerful quantitative tool to explore genome wide expression. The aim of this study is to provide a comprehensive RNA-Seq dataset across the same 13 tissues for mouse and rat, two of the most relevant species for biomedical research. The dataset provides the transcriptome across tissues from three male C57BL6 mice and three male Han Wistar rats. We also describe our bioinformatics pipeline to process and technically validate the data. Principal component analysis shows that tissue samples from both species cluster similarly. We show by comparative genomics that many genes with high sequence identity with respect to their human orthologues also have a highly correlated tissue di

SUBMITTER: Sollner JF 

PROVIDER: S-EPMC5726313 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature