Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study.

ABSTRACT:

Background

Cross-sectional studies have indicated impaired neurodevelopment with elevated drinking water manganese concentrations (W-Mn), but potential susceptible exposure windows are unknown.

Objectives

We prospectively evaluated the effects of W-Mn, from fetal life to school age, on children's cognitive abilities and behavior.

Methods

We assessed cognitive abilities and behavior in 1,265 ten-year-old children in rural Bangladesh using the Wechsler Intelligence Scale for Children (WISC-IV) and the Strengths and Difficulties Questionnaire (SDQ), respectively. Manganese in drinking water used during pregnancy and by the children at 5 y and 10 y was measured using inductively coupled plasma mass spectrometry.

Results

The median W-Mn was 0.20 mg/L (range 0.001–6.

SUBMITTER: Rahman SM 

PROVIDER: S-EPMC5726374 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature