Identifying consistent allele frequency differences in studies of stratified populations.

ABSTRACT: With increasing application of pooled-sequencing approaches to population genomics robust methods are needed to accurately quantify allele frequency differences between populations. Identifying consistent differences across stratified populations can allow us to detect genomic regions under selection and that differ between populations with different histories or attributes. Current popular statistical tests are easily implemented in widely available software tools which make them simple for researchers to apply. However, there are potential problems with the way such tests are used, which means that underlying assumptions about the data are frequently violated.These problems are highlighted by simulation of simple but realistic population genetic models of neutral evolution and the perfor

SUBMITTER: Wiberg RAW 

PROVIDER: S-EPMC5726381 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature