CMyc Regulates the Size of the Premigratory Neural Crest Stem Cell Pool.

ABSTRACT: The neural crest is a transient embryonic population that originates within the central nervous system (CNS) and then migrates into the periphery and differentiates into multiple cell types. The mechanisms that govern neural crest stem-like characteristics and self-renewal ability are poorly understood. Here, we show that the proto-oncogene cMyc is a critical factor in the chick dorsal neural tube, where it regulates the size of the premigratory neural crest stem cell pool. Loss of cMyc dramatically decreases the number of emigrating neural crest cells due to reduced self-renewal capacity, increased cell death, and shorter duration of the emigration process. Interestingly, rather than via E-Box binding, cMyc acts in the dorsal neural tube by interacting with another transcription factor, M

SUBMITTER: Kerosuo L 

PROVIDER: S-EPMC5726515 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature