Structural Integrity of Normal Appearing White Matter and Sex-Specific Outcomes After Acute Ischemic Stroke.

ABSTRACT:

Background and purpose

Women have worse poststroke outcomes than men. We evaluated sex-specific clinical and neuroimaging characteristics of white matter in association with functional recovery after acute ischemic stroke.

Methods

We performed a retrospective analysis of acute ischemic stroke patients with admission brain MRI and 3- to 6-month modified Rankin Scale score. White matter hyperintensity and acute infarct volume were quantified on fluid-attenuated inversion recovery and diffusion tensor imaging MRI, respectively. Diffusivity anisotropy metrics were calculated in normal appearing white matter contralateral to the acute ischemia.

Results

Among 319 patients with acute ischemic stroke, women were older (68.0 versus 62.7 years; P=0.004), had increased in

SUBMITTER: Etherton MR 

PROVIDER: S-EPMC5726524 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature