Bioinformatic analysis reveals new determinants of antigenic 14-3-3 proteins and a novel antifungal strategy.

ABSTRACT: The ubiquitously expressed 14-3-3 family of proteins is evolutionarily conserved from yeast to mammals. Their involvement in humoral and cellular immune responses is emerging through studies in drosophila and humans. In humans, a select group of 14-3-3 isoforms are antigenic; however the determinants of their antigenicity are not known. Here, we show that although mammalian 14-3-3 proteins are mostly conserved, subtle differences between their isoforms may give rise to their antigenicity. We observed syntenic relations among all the isoforms of 14-3-3 for mammals, but not with that of birds or amphibians. However, the parasitic 14-3-3 isoforms, which have known antigenic properties, show unique sequence, structure and evolution compared to the human 14-3-3. Moreover we report, for the firs

SUBMITTER: McGowan JE 

PROVIDER: S-EPMC5726717 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature