Dependence of prevalence of contiguous pathways in proteins on structural complexity.

ABSTRACT: Allostery is a regulatory mechanism in proteins where an effector molecule binds distal from an active site to modulate its activity. Allosteric signaling may occur via a continuous path of residues linking the active and allosteric sites, which has been suggested by large conformational changes evident in crystal structures. An alternate possibility is that the signal occurs in the realm of ensemble dynamics via an energy landscape change. While the latter was first proposed on theoretical grounds, increasing evidence suggests that such a control mechanism is plausible. A major difficulty for testing the two methods is the ability to definitively determine that a residue is directly involved in allosteric signal transduction. Statistical Coupling Analysis (SCA) is a method that has been s

SUBMITTER: Thayer KM 

PROVIDER: S-EPMC5726733 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature