Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5.

ABSTRACT:

Introduction

Amyloid-related decline in semantic memory was recently shown to be observable in the preclinical period of Alzheimer's disease. Cognitive composites designed to be sensitive to cognitive change in preclinical Alzheimer's disease (e.g., preclinical Alzheimer's cognitive composite [PACC]) and currently used in secondary prevention trials do not currently integrate measures of semantic processing. Our objective was to determine whether a standard semantic measure (i.e., category fluency [CAT] to animals, fruits, and vegetables) adds independent information above and beyond Aβ-related decline captured by the PACC.

Methods

Clinically normal older adults from the Harvard Aging Brain Study were identified at baseline as Aβ+ (n = 70) or Aβ- (n = 209) using Pittsburgh c

SUBMITTER: Papp KV 

PROVIDER: S-EPMC5726754 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature