Multisensory stimulation improves functional recovery and resting-state functional connectivity in the mouse brain after stroke.

ABSTRACT: Stroke causes direct structural damage to local brain networks and indirect functional damage to distant brain regions. Neuroplasticity after stroke involves molecular changes within perilesional tissue that can be influenced by regions functionally connected to the site of injury. Spontaneous functional recovery can be enhanced by rehabilitative strategies, which provides experience-driven cell signaling in the brain that enhances plasticity. Functional neuroimaging in humans and rodents has shown that spontaneous recovery of sensorimotor function after stroke is associated with changes in resting-state functional connectivity (RS-FC) within and across brain networks. At the molecular level, GABAergic inhibitory interneurons can modulate brain plasticity in peri-infarct and remote brain r

SUBMITTER: Hakon J 

PROVIDER: S-EPMC5726755 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature