P2Y₂ Nucleotide Receptor Prompts Human Cardiac Progenitor Cell Activation by Modulating Hippo Signaling.

ABSTRACT:

Rationale

Autologous stem cell therapy using human c-Kit⁺ cardiac progenitor cells (hCPCs) is a promising therapeutic approach for treatment of heart failure (HF). However, hCPCs derived from aged patients with HF with genetic predispositions and comorbidities of chronic diseases exhibit poor proliferative and migratory capabilities, which impair overall reparative potential for injured myocardium. Therefore, empowering functionally compromised hCPCs with proregenerative molecules ex vivo is crucial for improving the therapeutic outcome in patients with HF.

Objective

To improve hCPC proliferation and migration responses that are critical for regeneration by targeting proregenerative P2Y₂ nucleotide receptor (P2Y₂R) activated by extracellular

SUBMITTER: Khalafalla FG 

PROVIDER: S-EPMC5726767 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature