Ontology highlight
ABSTRACT:
SUBMITTER: Krepler C
PROVIDER: S-EPMC5726788 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Cell reports 20171101 7
Therapy of advanced melanoma is changing dramatically. Following mutational and biological subclassification of this heterogeneous cancer, several targeted and immune therapies were approved and increased survival significantly. To facilitate further advancements through pre-clinical in vivo modeling, we have established 459 patient-derived xenografts (PDX) and live tissue samples from 384 patients representing the full spectrum of clinical, therapeutic, mutational, and biological heterogeneity ...[more]