Central sensitization associated with low fetal hemoglobin levels in adults with sickle cell anemia.

ABSTRACT:

Background and aims

Pain is the hallmark of sickle cell anemia (SCA), presenting as recurrent acute events or chronic pain. Central sensitization, or enhanced excitability of the central nervous system, alters pain processing and contributes to the maintenance of chronic pain. Individuals with SCA demonstrate enhanced sensitivity to painful stimuli however central mechanisms of pain have not been fully explored. We hypothesized that adults with SCA would show evidence of central sensitization as observed in other diseases of chronic pain.

Methods

We conducted a prospective study of static and dynamic quantitative sensory tests in 30 adults with SCA and 30 matched controls.

Results

Static thermal testing using cold stimuli showed lower pain thresholds (p=0.04) and tole

SUBMITTER: Darbari DS 

PROVIDER: S-EPMC5726893 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature