Temporal expression profiling of plasma proteins reveals oxidative stress in early stages of Type 1 Diabetes progression.

ABSTRACT: Blood markers other than islet autoantibodies are greatly needed to indicate the pancreatic beta cell destruction process as early as possible, and more accurately reflect the progression of Type 1 Diabetes Mellitus (T1D). To this end, a longitudinal proteomic profiling of human plasma using TMT-10plex-based LC-MS/MS analysis was performed to track temporal proteomic changes of T1D patients (n=11) across 9 serial time points, spanning the period of T1D natural progression, in comparison with those of the matching healthy controls (n=10). To our knowledge, the current study represents the largest (>2000 proteins measured) longitudinal expression profiles of human plasma proteome in T1D research. By applying statistical trend analysis on the temporal expression patterns between T1D and contr

SUBMITTER: Liu CW 

PROVIDER: S-EPMC5726913 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature