Central nervous system-penetrating antiretrovirals impair energetic reserve in striatal nerve terminals.

ABSTRACT: The use of antiretroviral (ARV) drugs with central nervous system (CNS) penetration effectiveness (CPE) may be useful in the treatment of HIV-associated neurocognitive disorder (HAND) as well as targeting a CNS reservoir in strategies to achieve a functional cure for HIV. However, increased cognitive deficits are linked to at least one of these drugs (efavirenz). As mitochondrial dysfunction has been found with a number of ARVs, and as such can affect neuronal function, the objective of this study was to assess the effects of ARV with high CPE for toxicological profiles on presynaptic nerve terminal energy metabolism. This subcellular region is especially vulnerable in that a constant supply of ATP is required for the proper maintenance of neurotransmitter release and uptake supporting pro

SUBMITTER: Stauch KL 

PROVIDER: S-EPMC5726941 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature