Ontology highlight
ABSTRACT:
SUBMITTER: Humblin E
PROVIDER: S-EPMC5727025 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Humblin Etienne E Thibaudin Marion M Chalmin Fanny F Derangère Valentin V Limagne Emeric E Richard Corentin C Flavell Richard A RA Chevrier Sandy S Ladoire Sylvain S Berger Hélène H Boidot Romain R Apetoh Lionel L Végran Frédérique F Ghiringhelli François F
Nature communications 20171212 1
Interferon regulatory factors (IRF) have critical functions in lymphoid development and in immune response regulation. Although many studies have described the function of IRF4 in CD4<sup>+</sup> T cells, few have focused on the IRF4 homologue, IRF8. Here, we show that IRF8 is required for Th9 differentiation in vitro and in vivo. IRF8 functions through a transcription factor complex consisting of IRF8, IRF4, PU.1 and BATF, which binds to DNA and boosts Il9 transcription. By contrast, IRF8 defic ...[more]